Chlorine dioxide Dioxide: Chlorine Dioxide-Short-term-toxicity to fish.001

Chlorine dioxide

EC number: 233-162-8 | CAS number: 10049-04-4

http://www.qsartoolbox.org/de/web/guest/registration-dossier/-/registered-dossier/15450/6/2/2/?documentUUID=b03ad387-d74d-403a-98d5-2a120db368a9

Short-term toxicity to fish

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Administrative data

Purpose flag:

supporting study

Study result type:

experimental result

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

No guideline or GLP compliance stated

Data source

Reference

Reference Type:

publication

Title:

Acute and chronic toxicity of chlorine dioxide (ClO2) and Chlorite (ClO2-) to Rainbow Trout (Oncorhynchus mykiss)

Author:

Svecevicius G, Syvokiene J, Stasiunaite P and Mickeniene L

Year:

2005

Bibliographic source:

Environ Sci and Pollut Res, 12(5): 302 - 305

Materials and methods

Principles of method if other than guideline:

The aim of the study is to investigate sensitivity of rainbow trout to the acute toxicity of chlorine dioxide by exposing both larvae and dult fish to a 96-hour semi-static exposure.

GLP compliance:

no data

Test materials

Identity of test material same as for substance defined in section 1 (if not read-across):

yes

Test material identityopen allclose all

Test material identity 1

Test material identity 2

Test organisms

Test organisms (species):

Oncorhynchus mykiss

Details on test organisms:

* Larvae - age: 7-days old
* Adult - age: 1-year old
The fish were obtained from the Zeimena fish hatchery (Svencionys District, Lithuania), and acclimated to laboratory conditions at least one week before the initiation of the tests.

Study design

Test type:

semi-static

Water media type:

freshwater

Total exposure duration:

96 h

Test conditions

Hardness:

284 mg/L as CaCO3 (average)

Test temperature:

* for the larvae: 10 ± 0.5oC
* for adult fish: 12 ± 0.5oC

pH:

pH 8.0 (mean)

Dissolved oxygen:

8 - 10 mg/L

Details on test conditions:

Test solutions were renewed daily with a stock solution prepared at the start of the test

Results and discussion

Effect concentrationsopen allclose all

Effect concentrations 1

Effect concentrations 2

Details on results:

Exposure duration to chlorine dioxide evidently increased test larvae mortality, but no significant difference was found between 96-hour LC50 values. In general, rainbow trout larvae were 3.8 times more sensitive to the acute toxic effect of chlorine dioxide than adult fish, according to the 96-hour values. ClO2 induced evident changes in cardio-respiratory responses of rainbow trout larvae. Chlorine dioxide affected cardio-respiratory responses of larve even at lower test concentrations of 0.3, 0.6, 1.2 and 2.4 mg/L. 

Reported statistics and error estimates:

All the data obtained were treated with standard statistical procedures used in Toxicology. The median acutely lethal concentration (LC50) values and their 95% confidence intervals (CI) were calculated using the Trimmed Spearman-Karber Method. The Threshold Effect Concentration (TEC) was estimated for every parameter studied by defining geometric mean betwen the Lowest Observed Effect Concentration (LOEC) and the No Observed Effect Concentration (NOEC).

Applicant's summary and conclusion

Conclusions:

Larval rainbow trout was found to be more sensitive to chlorine dioxide than adult fish.