http://www.qsartoolbox.org/de/web/guest/registration-dossier/-/registered-dossier/15450/6/2/2/?documentUUID=0c017ce6-06dc-4d22-944f-01f8f0b85cd5
Chlorine Dioxide-Dossier: Chlorine Dioxide
Short-term toxicity to fish.013
Administrative data
- Purpose flag:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- No guideline or GLP compliance stated, but study well documented.
Data source
Reference
- Reference Type:
- publication
- Title:
- Pathology of fathead minnows (Pimephales promelas) exposed to chlorine dioxide and chlorite.
- Author:
- Yonkos LT, Fisher DJ, Wright DA and Kane AS
- Year:
- 2000
- Bibliographic source:
- Marine Environmental Research, 50: 267-271
Materials and methods
- GLP compliance:
- no data
Test materials
- Identity of test material same as for substance defined in section 1 (if not read-across):
- yes
Test material identityopen allclose all
Test organisms
- Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- Age: adult
Study design
- Test type:
- flow-through
- Total exposure duration:
- 12 h
- Post exposure observation period:
- 14 days recovery period
Test conditions
- Test temperature:
- 25°C
- Nominal and measured concentrations:
- 0.13 and 0.19 mg/L
Results and discussion
Effect concentrations
- Duration:
- 14 d
- Basis for effect:
- other: total recovery of gill epithelium
- Details on results:
- Gill epithelium was the primary large tissue affected by chlorine dioxide exposure. Treatment produced dose-dependent gill pathology including epithelial lifting, hypertrophy, hyperplasia, lamellar fusion and necrosis. Complete recovery, even in fish with severe hypertrophy and lamellar fusion, was achieved within 14 days.
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